Pharmacology Department
In
2011, among 32 African institutions selected as ANDI Centres of Excellence in
health innovation, TBRI represented by pharmacology laboratory; was assigned as
the“ANDI Centre of Excellence on Anti-Trematodal R&D”
by the Scientific and Technical Advisory Committee (STAC) of the African Network for Drugs and Diagnostics Innovation (ANDI).
Drug Evaluation and Discovery Unit (DEDU), a
subsidiary of pharmacology laboratory, will help in support and development of
the activities of the center. The excellence centre is willing to collaborate
with ANDI and with other African institutions with a focus on natural products,
to complement research lines regarding the prevalent endemic diseases, and to
increase our south-south collaboration to address specific health problems in
the African continent. Moreover, it is looking for exchange visits between
researchers with different capacities to help in building De Novo
capacities, leverage existing ones through not only exchange of visits but also
through training and execution of collaborative research projects.
The Head of Excellence Centre is Doctor Sanaa Botros, Professor of Pharmacology
The
activities of the centre include the following training programes:
1. In vitro testing of
antischistosomal activity of drugs/compounds (duration: one week). The programme
includes; preparation of culture media, different concentrations of
drugs/compounds, testing of worms’ viability/mortality, assessment and
comparison of different compound potencies (LC50) in comparison to
the reference compound.
Fees: 1500 EGP for Egyptians/800US$ for non Egyptians
The maximum
available places are 5-7 persons/programme.
2. In vivo testing of
antischistosomal activity of drugs/compounds (duration: one week). The
programme includes; animals handling, how to infect animals, routes of drug
administration, perfusion of animals, worm and egg counts, percentage egg
developmental stages (oogram
pattern) and determination of ED50 of drugs/compounds.
Fees: 2000EGP for Egyptians /1200US$for non-Egyptians
The maximum available places are 5-7
persons/programme.
3. Determination
of acute and chronic toxicity of drugs/compounds (duration: one week). The programme includes; determination of the three
cardinal parameters of mortality LD16, LD50 and LD84,
acute and chronic toxicity using low doses of LD50, biochemical
assessments and data interpretation.
Fees: 1500 EGP for Egyptians/500US$ for non-Egyptians
The
maximum available places are 5-7 persons/programme.
4. Isolation of
hepatocytes and cytotoxicity of compounds (duration: one week). The programme includes; preparation of
culture media and reagents, animals handling, perfusion of rat liver through
portal vein, isolation of hepatocytes and cytotoxicity testing (MTT or SRB)/
compound.
Fees:
3000EGP for Egyptians/ 2000US$ for non-Egyptians
The maximum available places are 3-5
persons/programme.
5. Bioavailability
of drugs/compounds (e.g Bioavailability of praziquantel (PZQ) &
Paracetamol) (duration: one week). The programme includes; preparation of
standards and reagents, extraction of drugs, sampEGP injection by HPLC and
calculation of pharmacokinetic data.
Fees: 2500 EGP for Egyptians/ 1500US$ for non-Egyptians.
The maximum
available places are 3-5 persons/programme.
التسميات:
Laboratory Division
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